Lars Edvinsson’s publications on stroke

Christensen ST, Johansson SE, Radziwon-Balicka A, Warfvinge K, Haanes KA, Edvinsson L. MEK1/2 inhibitor U0126, but not nimodipine, reduces upregulation of cerebrovascular contractile receptors after subarachnoid hemorrhage in rats. PLoS ONE. 2019; 14: e0215398.
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215398

Edvinsson L, Larsen SS, Maddahi A, Nielsen J. Plasticity of cerebrovascular smooth muscle cells after subarachnoid hemorrhage. Translational Stroke Research. 2014 Jun:5(3):365-76.
https://doi.org/10.1007/s12975-014-0331-4

Samraj AK, Müller AH, Grell A-S, Edvinsson L. Role of unphosphorylated transcription factor STAT3 in late cerebral ischemia after subarachnoid hemorrhage. J Cereb Blood Flow Metab. 2014:34(5):759-63.
https://doi.org/10.1038/jcbfm.2014.15

Parker B, Larsen MR, Edvinsson LIH, Povlsen GK. Signal transduction in cerebral arteries after subarachnoid hemorrhage a phosphoproteomic approach. J Cereb Blood Flow Metab. 2013;33(8):1259-69.
https://doi.org/10.1038/jcbfm.2013.78

Povlsen GK, Johansson SE. Larsen CC. Samraj AK. Edvinsson L. Early events triggering delayed vasoconstrictor receptor upregulation and cerebral ischemia after subarachnoid hemorrhage. BMC Neuroscience. 2013; 14:34.
https://doi.org/10.1186/1471-2202-14-34

Ansar S, Eftekhari S, Waldsee R, Nilsson E. Nilsson O, Säveland H et al. MAPK signaling pathway regulates cerebrovascular receptor expression in human cerebral arteries. BMC Neuroscience. 2013;14:12.
https://doi.org/10.1186/1471-2202-14-12

Maddahi A. Povlsen G. Edvinsson L. Regulation of enhanced cerebrovascular expression of proinflammatory mediators in experimental subarachnoid hemorrhage via the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase pathway. J Neuroinflammation. 2012;9:274.
https://doi.org/10.1186/1742-2094-9-274

Ahnstedt H. Säveland H. Nilsson O, Edvinsson L. Human cerebrovascular contractile receptors are upregulated via a B-Raf/MEK/ERK-sensitive signaling pathway. BMC Neuroscience. 2011; 12:5.
https://doi.org/10.1186/1471-2202-12-5

Larsen CC. Povlsen GK, Rasmussen MNP, Edvinsson L. Improvement in neurological outcome and abolition of cerebrovascular endothelin B and 5-hydroxytryptamine 1B receptor upregulation through mitogen-activated protein kinase kinase 1/2 inhibition after subarachnoid hemorrhage in rats. J Neurosurgery. 2011: 114(4):1143-53.
https://doi.org/10.3171/2010.6.JNS1018

Ansar S. Maddahi A, Edvinsson L. Inhibition of cerebrovascular raf activation attenuates cerebral blood flow and prevents upregulation of contractile receptors after subarachnoid hemorrhage. BMC Neuroscience. 2011:12:107.
https://doi.org/10.1186/1471-2202-12-107

Edvinsson L, Povlsen GK. Late cerebral ischemia after subarachnoid hemorrhage: is cerebrovascular receptor upregulation the mechanism behind? Acta Physiologica. 2011; 203(1):209-24.
https://doi.org/10.1111/j.1748-1716.2010.02227.x

Edvinsson LIH, Povlsen GK. Vascular plasticity in cerebrovascular disorders. J Cereb Blood Flow Metab. 2011; 31(7):1554-71.
https://doi.org/10.1038/jcbfm.2011.70

Spray S, Haanes KA, Edvinsson L, Johansson SE. Subacute phase of subarachnoid hemorrhage in female rats: Increased intracranial pressure, vascular changes and impaired sensorimotor function. Microvasc Res. 2021; 135:104127.
https://doi: 10.1016/j.mvr.2020.104127

Edvinsson L. Krause DN. Switching Off Vascular MAPK Signaling: A Novel Strategy to Prevent Delayed Cerebral Ischemia Following Subarachnoid Hemorrhage. Translational Stroke Research. 2024 Feb. 9. Epub 2024 9 Feb. doi: 10.1007/s12975-024-01234-z.
https://link.springer.com/article/10.1007/s12975-024-01234-z